This quote by Denzel Washington is one I can analyze all day long. There are many ways to look at what he is saying.
My first take on this is to talk about good vs. evil. Or you can look at this from the perspective of success, leadership, prosperity, etc. As you think about this quote, what is your interruption?
Does it matter to you if your spirit irritates them or, is it more imperative to be true to your vision? As long as. your energy is positive, causes no harm, pursue your passion, go irritate those demons.